Micro RNA‐30b (inhibitor) nanoparticles suppressed the lipopolysaccharide (LPS)‐induced acute kidney injury

NGAL, the New Marker for Acute Kidney Injury

Peroxiredoxin 6 overexpression attenuates lipopolysaccharide-induced acute kidney injury

Peroxiredoxin 6 (PRDX6) is a member of the PRDX family of antioxidant enzymes and correlated with inflammatory response. Therefore, we investigated the role of PRDX6 during lipopolysaccharide (LPS)-induced acute kidney injury. Both 3 months aged PRDX6-overexpressing transgenic mice (PRDX6 mice) and wild type (WT) mice had acute renal injury induced by intraperitoneal injection of LPS (10 mg/kg)...

Circulating micro-RNAs in acute kidney injury: early observations.

Acute kidney Injury (AKI) remains a diagnostic and therapeutic dilemma. Translation of excellent basic science information into therapeutic advances in AKI now depends on early diagnosis and drug delivery before elimination of the potential for this target to influence cell injury. For instance, treatment of ischemic AKI with small interfering RNA to P53 depends on glomerular filtration followe...

The acute liver injury in rat caused by gold nanoparticles

Objective(s):   Gold nanoparticles (GNPs) command a great deal of attention for biomedical applications nowadays. The data about the degree of toxicity and the accumulation of gold nanoparticles in-vivo is not enough to judge.  Materials and Methods:  A total of 32 healthy male Wistar rats were randomly divided into 4 including: three GNP-treated and one control group. Groups 1, 2 and 3 receive...

Amelioration of Acute Kidney Injury in Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome by an Aldose Reductase Inhibitor, Fidarestat

BACKGROUND Systemic inflammatory response syndrome is a fatal disease because of multiple organ failure. Acute kidney injury is a serious complication of systemic inflammatory response syndrome and its genesis is still unclear posing a difficulty for an effective treatment. Aldose reductase (AR) inhibitor is recently found to suppress lipopolysaccharide (LPS)-induced cardiac failure and its let...